There are two major stumbling blocks to developing effective drugs for Alzheimer’s, Parkinson’s, and other diseases that destroy the brain. The first is overcoming the blood-brain barrier, and the second is delivering the drug to a precise location and ensuring that it does not spread to the rest of the brain.
New research finds a way to target more precise locations in brains with Parkinson’s.
Now, a new approach that uses ultrasound beams and microbubbles could be a noninvasive way to deliver drugs safely to precise locations in the brain.
The technique is called focused ultrasound (FUS) and promises to open the door to thousands of drugs that could treat a range of brain conditions if they could cross the blood-brain barrier.
The scientists at Columbia University in the city of New York who developed the FUS device have now shown that it helped to curb early Parkinson’s disease progression and improve brain function in mice.
They describe the results in a recent Journal of Controlled Release study paper.
The FUS technique temporarily opens the blood-brain barrier in a specific part of the brain to allow drugs to reach just that part.
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